2023 Experiential Internship - Oncology Discovery Tumor Dependency (California)

Company: AbbVie
Location: Saint Louis
Posted on: March 20, 2023

Job Description:

About AbbVieAbbVie's mission is to discover and deliver innovative medicines that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas: immunology, oncology, neuroscience, eye care, virology, women's health, and gastroenterology, in addition to products and services across its Allergan Aesthetics portfolio.For more information about AbbVie, please visit us at www.abbvie.com.Follow @abbvie on Twitter, Facebook, Instagram, YouTube, and LinkedIn. Oncology Discovery Tumor Dependency Internship OverviewThe Tumor Dependency group within Oncology Discovery plays a key role in the identification and validation of novel targets that present cancer selective dependencies. Under supervision of a senior principal research scientist in the group, the Oncology Discovery Tumor Dependency Intern will primarily support elucidation of RNA metabolism mechanisms in solid tumors with specific focus on mRNA stability and splicing mechanisms.Key responsibilities include:

• Identify key RNA metabolism pathways impacting solid tumor cell cross talk with tumor suppressor gene functions through literature and bioinformatic analysis
• Develop and/or apply biological principles to support a hypothesis driven experimental plan to identify key players in the RNA metabolism pathway implicating cellular state
• Lead the execution of in vitro experiments to advance the biological concepts in support of role of RNA metabolism regulators as novel targets in oncogenesisMinimum Qualifications
  • Currently enrolled in university, pursuing a Bachelor's Degree in Biology, Molecular Biology, Biochemistry or related field
  • Must be enrolled in university during the internship period
  • Must possess critical thinking and problem-solving skills, including analysis
  • Self-motivated and able to work with limited supervision and direction. Can work both independently or as part of a team
  • Proficient in required software including Microsoft Office Suite including Word, Excel, PowerPoint, OutlookPreferred Qualifications
    • Ability to conduct and interpret scientific experiments, providing suggestions for additional experiments, including design and development of new assays
    • Hands on experience in nucleic acid extraction/purification and identification of different species of RNA
    • Proficient in lentiviral production and transduction, stable cell line development and CRISPR-Cas based gene editing
    • Experience utilizing multiple bioinformatics platform to confirm RNA species identification and functional implication
    • Expected graduation in between August 2023- December 2024Benefits and Amenities
      • Competitive pay
      • Travel, transportation and lodging support for eligible students
      • Break rooms stocked with complimentary coffee, tea, beverages, snacks, and cold breakfast items
      • Onsite caf-- and fitness center
      • Opportunity to connect with AbbVie leaders and scientistsEqual Employment OpportunityAt AbbVie, we value bringing together individuals from diverse backgrounds to develop new and innovative solutions for patients. As an equal opportunity employer we do not discriminate on the basis of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information gender identity or expression, sexual orientation, marital status, protected veteran status, or any other legally protected characteristic.Applicable to California Applicants Only
        • The below range is the range that we in good faith believe is the range of possible compensation for this role at the time of this posting. We may ultimately pay more or less than the posted range and this range is only applicable for jobs to be performed in California.
        • This range may be modified in the future.
        • The salary range is (minimum: $42,075 to maximum: $76,440)
        • Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole discretion unless and until paid and may be modified at the Company's sole discretion, consistent with the law.

Keywords: AbbVie, St. Louis , 2023 Experiential Internship - Oncology Discovery Tumor Dependency (California), Healthcare , Saint Louis, Missouri